Tedizolid Phosphate: a Next-Generation Oxazolidinone
نویسندگان
چکیده
منابع مشابه
Tedizolid Phosphate: a Next-Generation Oxazolidinone
Treatment of multidrug-resistant Gram-positive infections continues to challenge clinicians as the emergence of new resistance mechanisms outpaces introduction of novel antimicrobial agents. Tedizolid phosphate is a next-generation oxazolidinone with activity against both methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus spp. Tedizolid has consistently shown pote...
متن کاملTedizolid Phosphate (Sivextro)
INTRODUCTION Between 2001 and 2003, acute bacterial skin and skin structure infections (ABSSSIs) accounted for more than 11 million ambulatory care visits, with a visit rate of 410.7 per 10,000 persons.1 As a broader term, ABSSSI encompasses the following (Table 1):2–4 1. Cellulitis/erysipelas 2. Wound infection 3. Major cutaneous abscess This infection is characteristically identifi ed by a me...
متن کاملTedizolid: The First Once-Daily Oxazolidinone Class Antibiotic.
Tedizolid phosphate is the second commercially available oxazolidinone antibiotic, although the first one in class that is dosed once daily. It is a prodrug that is rapidly converted to the active compound tedizolid. Tedizolid has activity against a wide range of gram-positive pathogens, including methicillin-resistant Staphylococcus aureus. It is approved to treat acute bacterial skin and skin...
متن کاملComparative pharmacodynamics of the new oxazolidinone tedizolid phosphate and linezolid in a neutropenic murine Staphylococcus aureus pneumonia model.
Tedizolid phosphate (TR-701) is a novel oxazolidinone prodrug (converted to the active form tedizolid [TR-700]) with potent Staphylococcus aureus activity. The current studies characterized and compared the in vivo pharmacokinetic/pharmacodynamic (PD) characteristics of TR-701/TR-700 and linezolid against methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) in the...
متن کاملDalbavancin, tedizolid phosphate, oritavancin diphosphate, and vedolizumab.
Antibacterial agents Skin and skin structure infections are most often caused by Grampositive bacteria such as streptococci and staphylococci. The number of these infections that are caused by methicillin-resistant Staphylococcus aureus (MRSA) has rapidly increased in recent years in both the community and hospital settings. MRSA skin infections experienced in the community can usually be effec...
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ژورنال
عنوان ژورنال: Infectious Diseases and Therapy
سال: 2015
ISSN: 2193-8229,2193-6382
DOI: 10.1007/s40121-015-0060-3